| Pair Name | Resveratrol, Roscovitine | ||
| Phytochemical Name | Resveratrol (PubChem CID: 445154 ) | ||
| Anticancer drug Name | Roscovitine (PubChem CID: 160355 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Resveratrol, Roscovitine | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| Result | We propose that resveratrol inactivates COX-1 by a "hit-and-run" mechanism, and offers a basis for the design of selective COX-1 inactivators that work through a mechanism-based event at the peroxidase active site. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004 May 21;279(21):22727-37. doi: 10.1074/jbc.M314302200. | Click |
